Several methods designing large application programs using assembly language are introduced, They are related to overall design, program structure, file naming, variable naming, memory allocation and input/ output format. 本文从总体设计、程序结构、文件命名、变量命名、内存分配和输入输出格式等六个方面介绍了如何设计大型汇编语言应用程序的若干方法。